Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

Well-balanced mitochondrial fission and fusion processes are essential for nervous system development. Loss of function of the main mitochondrial fission mediator, dynamin-related protein 1 (Drp1), is lethal early during embryonic development or around birth, but the role of mitochondrial fission in...

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Publicat a:Cell Death Differ
Autors principals: Oettinghaus, B, Schulz, J M, Restelli, L M, Licci, M, Savoia, C, Schmidt, A, Schmitt, K, Grimm, A, Morè, L, Hench, J, Tolnay, M, Eckert, A, D'Adamo, P, Franken, P, Ishihara, N, Mihara, K, Bischofberger, J, Scorrano, L, Frank, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815974/
https://ncbi.nlm.nih.gov/pubmed/25909888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.39
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