Reversal of Impaired Hippocampal Long-term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

BACKGROUND: Angelman syndrome (AS) is a human neuropsychiatric disorder associated with autism, mental retardation, motor abnormalities, and epilepsy. In most cases, AS is caused by the deletion of the maternal copy of UBE3A gene, which encodes the enzyme ubiquitin ligase E3A, also termed E6-AP. A m...

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Détails bibliographiques
Auteurs principaux: Kaphzan, Hanoch, Hernandez, Pepe, Jung, Joo In, Cowansage, Kiriana K., Deinhardt, Katrin, Chao, Moses V., Abel, Ted, Klann, Eric
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368039/
https://ncbi.nlm.nih.gov/pubmed/22381732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.01.021
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