Reversal of Impaired Hippocampal Long-term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

BACKGROUND: Angelman syndrome (AS) is a human neuropsychiatric disorder associated with autism, mental retardation, motor abnormalities, and epilepsy. In most cases, AS is caused by the deletion of the maternal copy of UBE3A gene, which encodes the enzyme ubiquitin ligase E3A, also termed E6-AP. A m...

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Detalhes bibliográficos
Main Authors: Kaphzan, Hanoch, Hernandez, Pepe, Jung, Joo In, Cowansage, Kiriana K., Deinhardt, Katrin, Chao, Moses V., Abel, Ted, Klann, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368039/
https://ncbi.nlm.nih.gov/pubmed/22381732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.01.021
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