Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

Early cancers are avascular and hence, profoundly acidic. Pre-malignant cells must adapt to acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are adapted to grow in acidic conditions using SILAC proteomics and we reveal a significant upregulation of lysosomal...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Damaghi, Mehdi, Tafreshi, Narges K., Lloyd, Mark C., Sprung, Robert, Estrella, Veronica, Wojtkowiak, Jonathan W., Morse, David L., Koomen, John M., Bui, Marilyn M., Gatenby, Robert A, Gillies, Robert J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682176/
https://ncbi.nlm.nih.gov/pubmed/26658462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9752
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