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Phenotypic changes of acid-adapted cancer cells push them toward aggressiveness in their evolution in the tumor microenvironment

The inter- and intra-tumoral metabolic phenotypes of tumors are heterogeneous, and this is related to microenvironments that select for increased glycolysis. Increased glycolysis leads to decreased pH, and these local microenvironment effects lead to further selection. Hence, heterogeneity of phenot...

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Bibliografski detalji
Izdano u:Cell Cycle
Glavni autori: Damaghi, Mehdi, Gillies, Robert
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628657/
https://ncbi.nlm.nih.gov/pubmed/27635863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1231284
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