Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model

Interactions between cancer cells and their microenvironment are crucial for promoting tumor growth and invasiveness. In the tumor adaptive landscape model, hypoxic and acidic microenvironmental conditions reduce the fitness of cancer cells and significantly restrict their proliferation. This select...

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Bibliographic Details
Main Authors: Lee, Hyung-Ok, Silva, Ariosto S., Concilio, Susanna, Li, Yue-Sheng, Slifker, Michael, Gatenby, Robert A., Cheng, Jonathan D.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197231/
https://ncbi.nlm.nih.gov/pubmed/21859828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0304
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