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Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model

Interactions between cancer cells and their microenvironment are crucial for promoting tumor growth and invasiveness. In the tumor adaptive landscape model, hypoxic and acidic microenvironmental conditions reduce the fitness of cancer cells and significantly restrict their proliferation. This select...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Hyung-Ok, Silva, Ariosto S., Concilio, Susanna, Li, Yue-Sheng, Slifker, Michael, Gatenby, Robert A., Cheng, Jonathan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197231/
https://ncbi.nlm.nih.gov/pubmed/21859828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0304
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