SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

The Set8/PR-Set7/KMT5a methyltransferase plays critical roles in governing transcriptional regulation, cell cycle progression and tumorigenesis. Although CRL4(Cdt2) was reported to regulate Set8 stability, deleting the PIP motif only led to partial resistance to ultraviolet-induced degradation of Se...

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Pubblicato in:Nat Commun
Autori principali: Wang, Zhiwei, Dai, Xiangpeng, Zhong, Jiateng, Inuzuka, Hiroyuki, Wan, Lixin, Li, Xiaoning, Wang, Lixia, Ye, Xiantao, Sun, Liankun, Gao, Daming, Zou, Lee, Wei, Wenyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682171/
https://ncbi.nlm.nih.gov/pubmed/26666832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10185
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