SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

The Set8/PR-Set7/KMT5a methyltransferase plays critical roles in governing transcriptional regulation, cell cycle progression and tumorigenesis. Although CRL4(Cdt2) was reported to regulate Set8 stability, deleting the PIP motif only led to partial resistance to ultraviolet-induced degradation of Se...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Zhiwei, Dai, Xiangpeng, Zhong, Jiateng, Inuzuka, Hiroyuki, Wan, Lixin, Li, Xiaoning, Wang, Lixia, Ye, Xiantao, Sun, Liankun, Gao, Daming, Zou, Lee, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682171/
https://ncbi.nlm.nih.gov/pubmed/26666832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10185
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