טוען...
Perturbation of the conformational dynamics of an active-site loop alters enzyme activity
The role of internal dynamics in enzyme function is highly debated. Specifically, how small changes in structure far away from the reaction site alter protein dynamics and overall enzyme mechanisms is of wide interest in protein engineering. Using RNase A as a model, we demonstrate that elimination...
שמור ב:
| הוצא לאור ב: | Structure |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4680847/ https://ncbi.nlm.nih.gov/pubmed/26655472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.10.011 |
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