MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies

The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently mutated gene in malignant melanoma (MM) and papillary thyroid cancer (PTC) and is causally involved in malignant cell transformation. Mutated BRAF is associated with an aggressive disease phenotype, thus making it a...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Lankenau, Malori A., Patel, Ravi, Liyanarachchi, Sandya, Maharry, Sophia E., Hoag, Kevin W., Duggan, Megan, Walker, Christopher J., Markowitz, Joseph, Carson, William E., Eisfeld, Ann-Kathrin, de la Chapelle, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679059/
https://ncbi.nlm.nih.gov/pubmed/26582795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520390112
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