Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer

Long noncoding RNAs (lncRNAs) are important regulators of cellular homeostasis. However, their contribution to the cancer phenotype still needs to be established. Herein, we have identified a p53-induced lncRNA, TP53TG1, that undergoes cancer-specific promoter hypermethylation-associated silencing....

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Diaz-Lagares, Angel, Crujeiras, Ana B., Lopez-Serra, Paula, Soler, Marta, Setien, Fernando, Goyal, Ashish, Sandoval, Juan, Hashimoto, Yutaka, Martinez-Cardús, Anna, Gomez, Antonio, Heyn, Holger, Moutinho, Catia, Espada, Jesús, Vidal, August, Paúles, Maria, Galán, Maica, Sala, Núria, Akiyama, Yoshimitsu, Martínez-Iniesta, María, Farré, Lourdes, Villanueva, Alberto, Gross, Matthias, Diederichs, Sven, Guil, Sonia, Esteller, Manel
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127373/
https://ncbi.nlm.nih.gov/pubmed/27821766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608585113
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