Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

TP53 does not fully comply with the Knudson model [Knudson, A. G., Jr. (1971) Proc. Natl. Acad. Sci. USA 68, 820–823] in that a reduction of constitutional expression of p53 may be sufficient for tumor predisposition . This finding suggests a gene-dosage effect for p53 function. To determine whether...

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Main Authors: Yoon, Heejei, Liyanarachchi, Sandya, Wright, Fred A., Davuluri, Ramana, Lockman, Janet C., de la Chapelle, Albert, Pellegata, Natalia S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2002
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC137768/
https://ncbi.nlm.nih.gov/pubmed/12438652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242597299
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