Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

OBJECTIVES: Metronidazole, a mainstay treatment for Clostridium difficile infection (CDI), is often ineffective for severe CDI. Whilst this is thought to arise from suboptimal levels of metronidazole in the colon due to rapid absorption, empirical validation is lacking. In contrast, reutericyclin, a...

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Bibliografiska uppgifter
I publikationen:J Antimicrob Chemother
Huvudupphovsmän: Cherian, Philip T., Wu, Xiaoqian, Yang, Lei, Scarborough, Jerrod S., Singh, Aman P., Alam, Zahidul A., Lee, Richard E., Hurdle, Julian G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677261/
https://ncbi.nlm.nih.gov/pubmed/26286574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv231
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