Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

OBJECTIVES: Metronidazole, a mainstay treatment for Clostridium difficile infection (CDI), is often ineffective for severe CDI. Whilst this is thought to arise from suboptimal levels of metronidazole in the colon due to rapid absorption, empirical validation is lacking. In contrast, reutericyclin, a...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Cherian, Philip T., Wu, Xiaoqian, Yang, Lei, Scarborough, Jerrod S., Singh, Aman P., Alam, Zahidul A., Lee, Richard E., Hurdle, Julian G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677261/
https://ncbi.nlm.nih.gov/pubmed/26286574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv231
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