Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

OBJECTIVES: Metronidazole, a mainstay treatment for Clostridium difficile infection (CDI), is often ineffective for severe CDI. Whilst this is thought to arise from suboptimal levels of metronidazole in the colon due to rapid absorption, empirical validation is lacking. In contrast, reutericyclin, a...

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Bibliografiske detaljer
Udgivet i:J Antimicrob Chemother
Main Authors: Cherian, Philip T., Wu, Xiaoqian, Yang, Lei, Scarborough, Jerrod S., Singh, Aman P., Alam, Zahidul A., Lee, Richard E., Hurdle, Julian G.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677261/
https://ncbi.nlm.nih.gov/pubmed/26286574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv231
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