Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

OBJECTIVES: Metronidazole, a mainstay treatment for Clostridium difficile infection (CDI), is often ineffective for severe CDI. Whilst this is thought to arise from suboptimal levels of metronidazole in the colon due to rapid absorption, empirical validation is lacking. In contrast, reutericyclin, a...

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Bibliographische Detailangaben
Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Cherian, Philip T., Wu, Xiaoqian, Yang, Lei, Scarborough, Jerrod S., Singh, Aman P., Alam, Zahidul A., Lee, Richard E., Hurdle, Julian G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677261/
https://ncbi.nlm.nih.gov/pubmed/26286574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv231
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