Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

OBJECTIVES: Metronidazole, a mainstay treatment for Clostridium difficile infection (CDI), is often ineffective for severe CDI. Whilst this is thought to arise from suboptimal levels of metronidazole in the colon due to rapid absorption, empirical validation is lacking. In contrast, reutericyclin, a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Antimicrob Chemother
Egile Nagusiak: Cherian, Philip T., Wu, Xiaoqian, Yang, Lei, Scarborough, Jerrod S., Singh, Aman P., Alam, Zahidul A., Lee, Richard E., Hurdle, Julian G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2015
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677261/
https://ncbi.nlm.nih.gov/pubmed/26286574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv231
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