Mode of Action and Bactericidal Properties of Surotomycin against Growing and Nongrowing Clostridium difficile

Surotomycin (CB-183,315), a cyclic lipopeptide, is in phase 3 clinical development for the treatment of Clostridium difficile infection. We report here the further characterization of the in vitro mode of action of surotomycin, including its activity against growing and nongrowing C. difficile. This...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Alam, Mohammed Zahidul, Wu, Xiaoqian, Mascio, Carmela, Chesnel, Laurent, Hurdle, Julian G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538476/
https://ncbi.nlm.nih.gov/pubmed/26055381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01087-15
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