Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures

BACKGROUND: Chinese hamster ovary (CHO) cells are the main host for producing recombinant proteins with human therapeutic applications mainly because of their capability to perform proper folding and glycosylation processes. In addition, mild hypothermia is one of the main strategies for maximising...

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Publicado en:PLoS One
Autores principales: Vergara, Mauricio, Berrios, Julio, Martínez, Irene, Díaz-Barrera, Alvaro, Acevedo, Cristian, Reyes, Juan G., Gonzalez, Ramon, Altamirano, Claudia
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676689/
https://ncbi.nlm.nih.gov/pubmed/26659083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144224
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