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High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

In the biopharmaceutical sector, Chinese hamster ovary (CHO) cells have become the host of choice to produce recombinant proteins (r-proteins) due to their capacity for correct protein folding, assembly, and posttranslational modification. However, the production of therapeutic r-proteins in CHO cel...

詳細記述

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書誌詳細
主要な著者: Mauricio Vergara, Mauro Torres, Andrea Müller, Verónica Avello, Cristian Acevedo, Julio Berrios, Juan G Reyes, Norma A Valdez-Cruz, Claudia Altamirano
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2018-01-01
シリーズ:PLoS ONE
オンライン・アクセス:http://europepmc.org/articles/PMC6095543?pdf=render
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