Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures

BACKGROUND: Chinese hamster ovary (CHO) cells are the main host for producing recombinant proteins with human therapeutic applications mainly because of their capability to perform proper folding and glycosylation processes. In addition, mild hypothermia is one of the main strategies for maximising...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vergara, Mauricio, Berrios, Julio, Martínez, Irene, Díaz-Barrera, Alvaro, Acevedo, Cristian, Reyes, Juan G., Gonzalez, Ramon, Altamirano, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676689/
https://ncbi.nlm.nih.gov/pubmed/26659083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144224
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