Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins. However, their low protein productivity in culture is the main hurdle to overcome. Mild hypothermia has been established as an effective strategy to enhance protein specific product...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Torres, Mauro, Zúñiga, Roberto, Gutierrez, Matias, Vergara, Mauricio, Collazo, Norberto, Reyes, Juan, Berrios, Julio, Aguillon, Juan Carlos, Molina, Maria Carmen, Altamirano, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864046/
https://ncbi.nlm.nih.gov/pubmed/29566086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194510
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