Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins. However, their low protein productivity in culture is the main hurdle to overcome. Mild hypothermia has been established as an effective strategy to enhance protein specific product...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Torres, Mauro, Zúñiga, Roberto, Gutierrez, Matias, Vergara, Mauricio, Collazo, Norberto, Reyes, Juan, Berrios, Julio, Aguillon, Juan Carlos, Molina, Maria Carmen, Altamirano, Claudia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864046/
https://ncbi.nlm.nih.gov/pubmed/29566086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194510
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