High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells

In the biopharmaceutical sector, Chinese hamster ovary (CHO) cells have become the host of choice to produce recombinant proteins (r-proteins) due to their capacity for correct protein folding, assembly, and posttranslational modification. However, the production of therapeutic r-proteins in CHO cel...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vergara, Mauricio, Torres, Mauro, Müller, Andrea, Avello, Verónica, Acevedo, Cristian, Berrios, Julio, Reyes, Juan G., Valdez-Cruz, Norma A., Altamirano, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095543/
https://ncbi.nlm.nih.gov/pubmed/30114204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202098
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