Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs

[Image: see text] While a conserved tyrosine (Tyr) is found in oxidases, the roles of phenol ring pK(a) and reduction potential in O(2) reduction have not been defined despite many years of research on numerous oxidases and their models. These issues represent major challenges in our understanding o...

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Udgivet i:J Am Chem Soc
Main Authors: Yu, Yang, Lv, Xiaoxuan, Li, Jiasong, Zhou, Qing, Cui, Chang, Hosseinzadeh, Parisa, Mukherjee, Arnab, Nilges, Mark J., Wang, Jiangyun, Lu, Yi
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676419/
https://ncbi.nlm.nih.gov/pubmed/25672571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5109936
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