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Site-specific incorporation of unnatural amino acids into urate oxidase in Escherichia coli

Urate oxidase catalyzes the oxidation of uric acid with poor solubility to produce 5-hydroxyisourate and allantoin. Since allantoin is excreted in vivo, urate oxidase has the potential to be a therapeutic target for the treatment of gout. However, its severe immunogenicity limits its clinical applic...

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Detalhes bibliográficos
Main Authors: Chen, Mingjie, Cai, Lei, Fang, Zhengzhi, Tian, Hong, Gao, Xiangdong, Yao, Wenbing
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548377/
https://ncbi.nlm.nih.gov/pubmed/18596202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.034587.108
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