Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetrameric proteins that evoke electrical rhythmicity in specialized neurons and cardiomyocytes. The channels are activated by hyperpolarizing voltage but are also receptors for the intracellular ligand adenosine-3′,5′-cyclic...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Thon, Susanne, Schulz, Eckhard, Kusch, Jana, Benndorf, Klaus
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2015
Teme:
Channels and Transporters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675818/
https://ncbi.nlm.nih.gov/pubmed/26636938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.08.054
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