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Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels
Opening of hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels is controlled by membrane hyperpolarization and binding of cyclic nucleotides to the tetrameric cyclic nucleotide-binding domain (CNBD), attached to the C-linker (CL) disk. Confocal patch-clamp fluorometry revealed pro...
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| Published in: | Biophys J |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8008325/ https://ncbi.nlm.nih.gov/pubmed/33515603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.01.017 |
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