Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels

Opening of hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels is controlled by membrane hyperpolarization and binding of cyclic nucleotides to the tetrameric cyclic nucleotide-binding domain (CNBD), attached to the C-linker (CL) disk. Confocal patch-clamp fluorometry revealed pro...

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Bibliographic Details
Published in:Biophys J
Main Authors: Pfleger, Christopher, Kusch, Jana, Kondapuram, Mahesh, Schwabe, Tina, Sattler, Christian, Benndorf, Klaus, Gohlke, Holger
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008325/
https://ncbi.nlm.nih.gov/pubmed/33515603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.01.017
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