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All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner
Hyperpolarization-activated cyclic nucleotide–modulated (HCN) channels are tetramers that elicit electrical rhythmicity in specialized brain neurons and cardiomyocytes. The channels are dually activated by voltage and binding of cyclic adenosine monophosphate (cAMP) to their four cyclic nucleotide-b...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6122924/ https://ncbi.nlm.nih.gov/pubmed/29959170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711935 |
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