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All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

Hyperpolarization-activated cyclic nucleotide–modulated (HCN) channels are tetramers that elicit electrical rhythmicity in specialized brain neurons and cardiomyocytes. The channels are dually activated by voltage and binding of cyclic adenosine monophosphate (cAMP) to their four cyclic nucleotide-b...

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Bibliografische gegevens
Gepubliceerd in:J Gen Physiol
Hoofdauteurs: Sunkara, Mallikarjuna Rao, Schwabe, Tina, Ehrlich, Gunter, Kusch, Jana, Benndorf, Klaus
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122924/
https://ncbi.nlm.nih.gov/pubmed/29959170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711935
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