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All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner
Hyperpolarization-activated cyclic nucleotide–modulated (HCN) channels are tetramers that elicit electrical rhythmicity in specialized brain neurons and cardiomyocytes. The channels are dually activated by voltage and binding of cyclic adenosine monophosphate (cAMP) to their four cyclic nucleotide-b...
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| Опубликовано в: : | J Gen Physiol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Rockefeller University Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6122924/ https://ncbi.nlm.nih.gov/pubmed/29959170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711935 |
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