Alpha imaging confirmed efficient targeting of CD45-positive cells after astatine-211 ((211)At)-radioimmunotherapy for hematopoietic cell transplantation

Alpha-radioimmunotherapy targeting CD45 may substitute for total body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (MAb; CA12.10C12) protein dose for astatine-211 ((211)At)-radioimmunotherapy, ex...

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Détails bibliographiques
Publié dans:J Nucl Med
Auteurs principaux: Frost, Sofia H.L., Miller, Brian W., Bäck, Tom A., Santos, Erlinda B., Hamlin, Donald K., Knoblaugh, Sue E., Frayo, Shani L., Kenoyer, Aimee L., Storb, Rainer, Press, Oliver W., Wilbur, D. Scott, Pagel, John M., Sandmaier, Brenda M.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675464/
https://ncbi.nlm.nih.gov/pubmed/26338894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.115.162388
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