Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

α-Emitting radionuclides deposit a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD). To evaluate this hypothesis, (211)At-labeled 1F5 monoclonal antibody (mAb) (anti-CD20) was studied in both bulky ly...

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Udgivet i:Blood
Main Authors: Green, Damian J., Shadman, Mazyar, Jones, Jon C., Frayo, Shani L., Kenoyer, Aimee L., Hylarides, Mark D., Hamlin, Donald K., Wilbur, D. Scott, Balkan, Ethan R., Lin, Yukang, Miller, Brian W., Frost, Sofia H. L., Gopal, Ajay K., Orozco, Johnnie J., Gooley, Theodore A., Laird, Kelly L., Till, Brian G., Bäck, Tom, Sandmaier, Brenda M., Pagel, John M., Press, Oliver W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375108/
https://ncbi.nlm.nih.gov/pubmed/25628467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-612770
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