Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with Alpha-Alpha Domain Architecture that Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence

Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two distinct active sites are required for catalysis: the N-terminal domain catalyzes the ionization and cyclization of farnesyl diphosphate to form g...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Harris, Golda G., Lombardi, Patrick M., Pemberton, Travis A., Matsui, Tsutomu, Weiss, Thomas M., Cole, Kathryn E., Köksal, Mustafa, Murphy, Frank V., Vedula, L. Sangeetha, Chou, Wayne K.W., Cane, David E., Christianson, David W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674366/
https://ncbi.nlm.nih.gov/pubmed/26598179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01143
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