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Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase
Aristolochene synthase (ATAS) is a high-fidelity terpenoid cyclase that converts farnesyl diphosphate exclusively into the bicyclic hydrocarbon aristolochene. Previously-determined crystal structures of ATAS complexes revealed trapped active site water molecules that could potentially interact with...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4879067/ https://ncbi.nlm.nih.gov/pubmed/27172425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00343 |
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