Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase

Aristolochene synthase (ATAS) is a high-fidelity terpenoid cyclase that converts farnesyl diphosphate exclusively into the bicyclic hydrocarbon aristolochene. Previously-determined crystal structures of ATAS complexes revealed trapped active site water molecules that could potentially interact with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Chen, Mengbin, Chou, Wayne K. W., Al-Lami, Naeemah, Faraldos, Juan A., Allemann, Rudolf K., Cane, David E., Christianson, David W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879067/
https://ncbi.nlm.nih.gov/pubmed/27172425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00343
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