Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with Alpha-Alpha Domain Architecture that Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence

Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two distinct active sites are required for catalysis: the N-terminal domain catalyzes the ionization and cyclization of farnesyl diphosphate to form g...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Harris, Golda G., Lombardi, Patrick M., Pemberton, Travis A., Matsui, Tsutomu, Weiss, Thomas M., Cole, Kathryn E., Köksal, Mustafa, Murphy, Frank V., Vedula, L. Sangeetha, Chou, Wayne K.W., Cane, David E., Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674366/
https://ncbi.nlm.nih.gov/pubmed/26598179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01143
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