Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase

Aristolochene synthase, a metal-dependent sesquiterpene cyclase from Aspergillus terreus, catalyzes the ionization-dependent cyclization of farnesyl diphosphate (FPP) to form the bicyclic eremophilane (+)-aristolochene with perfect structural and stereochemical precision. Here, we report the X-ray c...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Mengbin, Al-lami, Naeemah, Janvier, Marine, D'Antonio, Edward L., Faraldos, Juan A., Cane, David E., Allemann, Rudolf K., Christianson, David W.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755762/
https://ncbi.nlm.nih.gov/pubmed/23905850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400691v
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items