Development of homogeneous luminescence assays for histone demethylase catalysis and binding

Covalent modifications to histones play important roles in chromatin dynamics and the regulation of gene expression. The JmjC-containing histone demethylases (HDMs) catalyse the demethylation of methylated lysine residues on histone tails. Here we report the development of homogeneous luminescence b...

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Détails bibliographiques
Publié dans:Anal Biochem
Auteurs principaux: Kawamura, Akane, Tumber, Anthony, Rose, Nathan R., King, Oliver N. F., Daniel, Michelle, Oppermann, Udo, Heightman, Tom D., Schofield, Christopher
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673899/
https://ncbi.nlm.nih.gov/pubmed/20435012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.04.030
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