Resolution of stepwise cooperativities of copper binding by the homotetrameric copper sensitive operon repressor (CsoR): Impact on structure and stability()

The cooperativity of ligand binding is central to biological regulation and new approaches are needed to quantify these allosteric relationships. Herein, we exploit a suite of mass spectrometry (MS) experiments to provide novel insights into homotropic Cu-binding cooperativity, gas-phase stabilities...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Jacobs, Alexander D., Chang, Feng-Ming James, Morrison, Lindsay, Dilger, Jonathan M., Wysocki, Vicki H., Clemmer, David E., Giedroc, David P.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673887/
https://ncbi.nlm.nih.gov/pubmed/26332992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506349
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