Response to Copper Stress in Streptomyces lividans Extends beyond Genes under Direct Control of a Copper-sensitive Operon Repressor Protein (CsoR)

A copper-sensitive operon repressor protein (CsoR) has been identified in Streptomyces lividans (CsoR(Sl)) and found to regulate copper homeostasis with attomolar affinity for Cu(I). Solution studies reveal apo- and Cu(I)-CsoR(Sl) to be a tetramer assembly, and a 1.7-Å resolution crystal structure o...

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Hauptverfasser: Dwarakanath, Srivatsa, Chaplin, Amanda K., Hough, Michael A., Rigali, Sébastien, Vijgenboom, Erik, Worrall, Jonathan A. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366776/
https://ncbi.nlm.nih.gov/pubmed/22451651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352740
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