Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization

Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a promising anticancer drug due to its tumor-selective cytotoxicity. Here we report that TRAIL exhibits distinct effects on the mitochondrial networks in malignant cells and normal cells. Live-cell imaging revealed...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Suzuki-Karasaki, Yoshihiro, Fujiwara, Kyoko, Saito, Kosuke, Suzuki-Karasaki, Miki, Ochiai, Toyoko, Soma, Masayoshi
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673287/
https://ncbi.nlm.nih.gov/pubmed/26057632
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