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Aspirin Induces Mitochondrial Ca(2+) Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca(2+) Entry
Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms. Depolarization of the plasma membrane potential leads to voltage-gated Ca(2+) entry (VGCE) and caspase-3 activation. In the present st...
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| Publicat a: | Int J Mol Sci |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7370041/ https://ncbi.nlm.nih.gov/pubmed/32635638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21134771 |
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