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Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells

Lysosomes are lined with a glycocalyx that protects the limiting membrane from the action of degradative enzymes. We tested the hypothesis that Niemann-Pick type C 1 (NPC1) protein aids the transfer of low density lipoprotein-derived cholesterol across this glycocalyx. A prediction of this model is...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Li, Jian, Deffieu, Maika S., Lee, Peter L., Saha, Piyali, Pfeffer, Suzanne R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672801/
https://ncbi.nlm.nih.gov/pubmed/26578804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520490112
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