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Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells
Lysosomes are lined with a glycocalyx that protects the limiting membrane from the action of degradative enzymes. We tested the hypothesis that Niemann-Pick type C 1 (NPC1) protein aids the transfer of low density lipoprotein-derived cholesterol across this glycocalyx. A prediction of this model is...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4672801/ https://ncbi.nlm.nih.gov/pubmed/26578804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520490112 |
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