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Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2
Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann–Pick C1 (NPC1) and a soluble protein, Niemann–Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann–Pick disease type C (NPC). NPC2 binds to NPC1’s second (midd...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5018801/ https://ncbi.nlm.nih.gov/pubmed/27551080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611956113 |
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