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Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann–Pick C1 (NPC1) and a soluble protein, Niemann–Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann–Pick disease type C (NPC). NPC2 binds to NPC1’s second (midd...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Li, Xiaochun, Saha, Piyali, Li, Jian, Blobel, Günter, Pfeffer, Suzanne R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018801/
https://ncbi.nlm.nih.gov/pubmed/27551080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611956113
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