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Niemann–Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

Niemann–Pick type C1 (NPC1) protein is needed for cellular utilization of low-density lipoprotein-derived cholesterol that has been delivered to lysosomes. The protein has 13 transmembrane domains, three large lumenal domains, and a cytoplasmic tail. NPC1’s lumenally oriented, N-terminal domain bind...

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Autori principali: Deffieu, Maika S., Pfeffer, Suzanne R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223457/
https://ncbi.nlm.nih.gov/pubmed/22065762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110439108
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