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Niemann–Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding
Niemann–Pick type C1 (NPC1) protein is needed for cellular utilization of low-density lipoprotein-derived cholesterol that has been delivered to lysosomes. The protein has 13 transmembrane domains, three large lumenal domains, and a cytoplasmic tail. NPC1’s lumenally oriented, N-terminal domain bind...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2011
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223457/ https://ncbi.nlm.nih.gov/pubmed/22065762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110439108 |
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