Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ–RhoGEF

PDZ domains are abundant protein interaction modules and typically recognize a short motif at the C terminus of their ligands, with a few residues in the motif endowing the binding specificity. The sequence-based rules, however, cannot fully account for the specificity between the vast number of PDZ...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pascoe, Heath G., Gutowski, Stephen, Chen, Hua, Brautigam, Chad A., Chen, Zhe, Sternweis, Paul C., Zhang, Xuewu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672773/
https://ncbi.nlm.nih.gov/pubmed/26627240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508931112
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