Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A

BACKGROUND: Animal models that mimic human biology are important for successful translation of basic science discoveries into the clinical practice. Recent studies in rodents have demonstrated the efficacy of TLR4 agonists as immunomodulators in models of infection. However, rodent models have been...

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Bibliographic Details
Published in:PLoS One
Main Authors: Enkhbaatar, Perenlei, Nelson, Christina, Salsbury, John R., Carmical, Joseph R., Torres, Karen E. O., Herndon, David, Prough, Donald S., Luan, Liming, Sherwood, Edward R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671644/
https://ncbi.nlm.nih.gov/pubmed/26640957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144345
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