STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke

Oxidative stress is a major brain injury mechanism after ischemic stroke. 12/15-lipoxygenase (12/15-LOX) is a key mediator of oxidative stress, contributing to neuronal cell death and vascular leakage. Nonetheless, the mechanism leading to its upregulation is currently unknown. We show here that Sig...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Jung, Joo Eun, Karatas, Hulya, Liu, Yu, Yalcin, Ayfer, Montaner, Joan, Lo, Eng H, van Leyen, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671126/
https://ncbi.nlm.nih.gov/pubmed/26174325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.169
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