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STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke
Oxidative stress is a major brain injury mechanism after ischemic stroke. 12/15-lipoxygenase (12/15-LOX) is a key mediator of oxidative stress, contributing to neuronal cell death and vascular leakage. Nonetheless, the mechanism leading to its upregulation is currently unknown. We show here that Sig...
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| Veröffentlicht in: | J Cereb Blood Flow Metab |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4671126/ https://ncbi.nlm.nih.gov/pubmed/26174325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.169 |
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