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12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

12/15-Lipoxygenase (12/15-LOX) is an important mediator of brain injury following experimental stroke in rodents. It contributes to neuronal death, but the underlying mechanism remains unclear. We demonstrate here that in neuronal HT22 cells subjected to glutamate-induced oxidative stress, 12/15-LOX...

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Detalhes bibliográficos
Main Authors: Pallast, Stefanie, Arai, Ken, Wang, Xiaoying, Lo, Eng H., van Leyen, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773137/
https://ncbi.nlm.nih.gov/pubmed/19737346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06379.x
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