In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-X(L) and Mcl-1 but in the absence of active BH3-only proteins

Mitochondrial apoptosis is controlled by proteins of the B-cell lymphoma 2 (Bcl-2) family. Pro-apoptotic members of this family, known as BH3-only proteins, initiate activation of the effectors Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak), which is counteracted by an...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Senft, D, Weber, A, Saathoff, F, Berking, C, Heppt, M V, Kammerbauer, C, Rothenfusser, S, Kellner, S, Kurgyis, Z, Besch, R, Häcker, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670944/
https://ncbi.nlm.nih.gov/pubmed/26610208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.341
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