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Identification of the HIV-1 Vif and human APOBEC3G protein interface

Human cells express natural antiviral proteins, such as APOBEC3G (A3G) that potently restrict HIV replication. As a counter defense, HIV encodes the accessory protein Vif, which binds A3G and mediates its proteasomal degradation. Our structural knowledge on how Vif and A3G interact is very limited s...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Letko, Michael, Booiman, Thijs, Kootstra, Neeltje, Simon, Viviana, Ooms, Marcel
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670588/
https://ncbi.nlm.nih.gov/pubmed/26628364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.068
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